Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
7
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Read More
8
We conducted an open-label study to assess how a seaweed extract formulation, which includes Vitamin B6, impacts knee osteoarthritis symptoms. Involving 12 participants with confirmed knee osteoarthritis, we divided them into two groups receiving either 100 mg or 1000 mg of the extract daily.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
Read More
Most Useful Reviews
7.5
Relieved tension
3 people found this helpful
The product is excellent. I initially suffered from knee pain alongside symptoms of Vitamin B12 deficiency, such as joint discomfort and muscle tension. After using this product for just two days, it alleviated much of the tension. I used it for ten days and found great improvement. The quality is superb, with a pleasant sweet taste, and the packaging lasts a long time since it’s only needed during symptom flare-ups. Overall, I experienced significant health benefits.
Read More
7.5
Pain subsided
I was experiencing knee pain in my feet, but after about three days of using this product, the discomfort subsided.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We conducted an open-label study to assess how a seaweed extract formulation, which includes Vitamin B6, impacts knee osteoarthritis symptoms. Involving 12 participants with confirmed knee osteoarthritis, we divided them into two groups receiving either 100 mg or 1000 mg of the extract daily.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
Read More
7
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Relieved tension
3 people found this helpful
The product is excellent. I initially suffered from knee pain alongside symptoms of Vitamin B12 deficiency, such as joint discomfort and muscle tension. After using this product for just two days, it alleviated much of the tension. I used it for ten days and found great improvement. The quality is superb, with a pleasant sweet taste, and the packaging lasts a long time since it’s only needed during symptom flare-ups. Overall, I experienced significant health benefits.
Read More
7.5
Pain subsided
I was experiencing knee pain in my feet, but after about three days of using this product, the discomfort subsided.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Myers SP, O'Connor J, Fitton JH, Brooks L, Rolfe M, et al. A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis. Biologics. 2010;4:33.
- Liu Z, Chen Z, Wu Z, Tang M, Lin Y, et al. Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:973. doi:10.1186/s12891-024-08095-5
